The year's highlight for Dr. Price? Launching the world's 1st center for #FUS#cancerimmunotherapy? Nope - it's his lab! "From my office I overhear them raising each other up through new challenges on a daily basis. It's inspiring.” @PriceLabUVaBME
MORE: bit.ly/fus-win
An @OhioState expert explains how immunotherapy and other immuno-oncology treatments harness patients' own bodies to target and kill cancer cells. health.osu.edu/health/cancer…
Interesting, as median PFS differences was only 1.5 months. Suggests PFS is not a terrific surrogate for OS in ER+ advanced breast cancer which would have major implications for many drugs in development.
All due respect to rad onc colleagues, but I once said would be great to get rid of RT (and high dose CDDP) for advanced SCCHN using early #cancerimmunotherapy and med onc collegue said "you're dreaming, getting rid of RT aint never going to happen" 😀
Yet again more data indirectly suggesting the negative effects of high dose alkylators like cisplatin causing immune system impairment and/or selecting resistant #cancer cells to later line #cancerimmunotherapy in advanced SCCHN.
Neoadjuvant IO, whether alone or in combination, can lead to pCR. In this study, if 1/3 patients has pCR, do we need adjuvant RT? Why not substitute adjuvant IO? Worth studying.
aacrjournals.org/clincancerr…
Long-standing problem of Ag loss variants continues to remain problematic and fuels work into immunosurveillance, immunoediting, clonality, targeting multiple neoantigens & underappreciated bystander contributions to successful #cancerimmunotherapy
More excellent work on Ag presenting cells, T1 cytokine loops & underappreciated need for CD4 activation/regulation help in effector mechanisms of #cancerimmunotherapy in this model #immunotherapy#immunology
SPOTLIGHT: Neoantigen Presentation and IFNγ Signaling on the Same Tumor-associated Macrophage are Necessary for CD4 T [...] @AperezdiezDiez. Originally published in @CRC_AACR. To read our summary click ow.ly/YI8850KgytZ and scroll all the way down.
Find out how scientists at the @NIH, led by Dr. John T. Schiller, have developed a new immunotherapy strategy to awaken immune responses within the tumor microenvironment and promote antigen spreading.
#CancerImmunotherapy#Immunology#Research#Health#Science
Ag presentation loss has been known for decades to be associated with poor outcomes to various #cancerimmunotherapy approaches. Many #cancer#molecularprofiling companies don't include HLA expression. Brought it up at #ASCO22 & young panelist called it "hubris."😀 Kudos @vib_ccb
About 50-60% of advanced melanoma patients do not respond to immunotherapy. Why and what can we do about it? In this preprint we describe a prospective longitudinal clinical study we designed/conducted to address this (1/9). biorxiv.org/cgi/content/shor…
Watch our interview with Dr. @ChiappinelliLab, 2022 Cancer Research Early Career Award recipient, discussing her article on epigenetic drugs in #OvarianCancer and the role of p53 in altering repetitive DNA transcription.
bit.ly/3Pk0SME@GWSMHS@GWCancer