ValerioCoronel retweeted
Él cáncer es la 2da causa principal de ☠️ entre los receptores de trasplantes. En pxs con #TR el riesgo aumenta 2 a 3 veces, en comparación con la población.
Él riesgo también aumento con los Ca relacionados c/🦠 como #PTLD
doi.org/10.2215/CJN.14570920
@AvelRomanNeph
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Post-transplant lymphoproliferative disorder (#PTLD)seen in severely immunosuppressed.
Fever, lymphadenopathy & lymphomatous infiltrates in lymph nodes, spleen, liver, bone marrow, kidney & lung are typical.
Ref GWIDBR
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COVID dose #4 + 6 “new” vaccinations. As someone who grew up with an undiagnosed primary immune deficiency, and is now post bone marrow transplant, and a #ptld survivor, every vaccination feels like a victory and a miracle.
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The closet is officially open - time to see what is inside. Like, share and comment.#ChurchBoyChronicles #PTLD
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The patient depicted had kidney SOT #PTLD #DLBCL (and molecular double hit to boot) so likely w/ prominent T-cell suppression/exhaustion.
👀 Still fascinating nonetheless to have good CR to 20/3 Bispecific after blowing through 5 previous consecutive therapies (no response x 5).
The population-pharmacokinetic models of CART suggest that some failures could be inadequate CART expansion. So it's plausible that CD20 could remain a viable target for another approach like 20/3 bispecific t-cell engager.
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Anecdotes but have several successful salvage examples (w/ Tafa-Len & esp CD20/3 bispecific Ab). Eg of latter: 69 yoF w/ molec double hit (myc/bcl2) monomorphic #DLBCL #PTLD w/ primary quintuple refractory disease (never responded) to R-EPOCH, ICE, CD20 CART, Polivy, Monjuvi) 1/2
Dunno…early relapse after 1L is data-free with tafa-len given L-MIND inclusion, and not sure I’d bank on 20:3 after POD through a CD20 CAR…challenging case.
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Impacted by #PostTransplant #LymphoproliferativeDisorder (#PTLD)? Your story matters!
@RareDiseases is hosting an externally-led Patient-Focused Drug Development meeting on Wednesday, May 4. Register to attend, share your experiences, and be heard: bit.ly/PTLD-PFDD
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Impacted by #PostTransplant #LymphoproliferativeDisorder (#PTLD)? Your story matters!
@RareDiseases is hosting an externally-led Patient-Focused Drug Development meeting on Wednesday, May 4. Register to attend, share your experiences, and be heard: bit.ly/PTLD-PFDD
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Epstein–Barr virus (EBV) is something most people do not think about, or even know about. However, after my son’s liver transplant due to Alagille syndrome (ALGS), it is a big worry. fal.cn/3og3S
#AlagilleSyndrome #ALGS #Alagille #LiverTransplant #EpsteinBarr #PTLD
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Affected by #ptld post #transplant? Join us for this historic meeting with the @US_FDA hosted by @RareDiseases It is important patients and caregivers join to share their #ptexp w/ the disease & educate what they want when developing and approving drugs
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Marisa's parents are honored to be able to share Marisa’s courageous #PTLD journey with @RareDiseases for a patient-focused drug development meeting with @US_FDA leaders that may impact treatment of the rare form of cancer that claimed Marisa's life. marisatufarofoundation.org/r…
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#NHL #DLBCL #FL #MCL #PTCL #PTLD #CLL #CTCL #CAR-T
📢📢📢Glad to share an excellent #SpecialIssue "Advancing the Care of Non-Hodgkins Lymphoma (NHL): Steps Towards Being Chemo-Free" edited by Owen A. O’Connor and Francesca Montanari! @UVALibrary @Yale
🔗jcmtjournal.com/journal/spec…
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I Finish Something I Been Working On For The Past Few Months And Happy To Release It [PIGGY: The Lost Dimension] Still Has Some Bug But I'm Fixing It.
Game Link ⬇
scratch.mit.edu/projects/673…
YouTube Link ⬇
invidio.us/watch?v=EtlSM66Z…
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